END-USER LICENSE AGREEMENT (EULA) FOR BIOSHIFT This End-User License Agreement ("Agreement") is a legal agreement between you ("Licensee" or "you") and Titan Digitalsoft ("Licensor" or "we") for the Bioshift software application ("Software") and related materials ("Materials"). BY INSTALLING, COPYING, OR OTHERWISE USING THE SOFTWARE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS OF THIS AGREEMENT. IF YOU DO NOT AGREE TO THE TERMS AND CONDITIONS OF THIS AGREEMENT, DO NOT INSTALL, COPY, OR USE THE SOFTWARE. 1. DEFINITIONS 1.1 "Bioshift" means the computational chemistry and bioinformatics workflow platform software application, including all compiled binaries, executables, libraries, data files, documentation, and related materials provided by Titan Digitalsoft. 1.2 "Licensee" means the individual or entity that has acquired a valid license to use the Software. 1.3 "Computer" means a single physical or virtual machine on which the Software is installed and used. 1.4 "Materials" means all documentation, user guides, tutorials, example files, configuration files, and other materials provided with the Software. 2. GRANT OF LICENSE 2.1 Subject to the terms and conditions of this Agreement, Titan Digitalsoft hereby grants you a non-exclusive, non-transferable, limited license to install and use the Software on a single Computer for your personal or internal business purposes. 2.2 You may: (a) Install and use the Software on one Computer; (b) Make one backup copy of the Software for archival purposes only; (c) Use the Materials for reference purposes in connection with your use of the Software; (d) Access and use integrated third-party tools and libraries as provided within the Software bundle. 2.3 You may not: (a) Distribute, rent, lease, lend, or otherwise transfer the Software or any portion thereof to any third party; (b) Modify, adapt, translate, reverse engineer, decompile, disassemble, or create derivative works based on the Software; (c) Remove or alter any copyright, trademark, or other proprietary notices contained in the Software; (d) Use the Software for any commercial purpose without obtaining a separate commercial license from Titan Digitalsoft; (e) Extract, separate, or use any individual component, library, or tool from the Software bundle independently; (f) Share or distribute any Materials, documentation, or example files provided with the Software. 3. INTELLECTUAL PROPERTY RIGHTS 3.1 The Software and Materials are protected by copyright laws and international copyright treaties, as well as other intellectual property laws and treaties. 3.2 All title, ownership rights, and intellectual property rights in and to the Software and Materials (including but not limited to any images, photographs, animations, video, audio, music, text, and "applets" incorporated into the Software), and any copies you are permitted to make under this Agreement, are owned by Titan Digitalsoft or its suppliers. 3.3 The Software is licensed, not sold. This Agreement does not grant you any rights to trademarks or service marks of Titan Digitalsoft. 3.4 Third-party components included in the Software bundle are subject to their respective licenses, which are incorporated herein by reference. These components include but are not limited to: - AutoDock Vina (Molecular docking software) - GROMACS (Molecular dynamics simulation package) - OpenBabel (Chemical format conversion toolkit) - RDKit (Cheminformatics toolkit) - PySide6/Qt (GUI framework) - Various Python libraries and scientific computing tools 4. THIRD-PARTY INTEGRATIONS AND DATA SOURCES 4.1 The Software includes integrations with various third-party services and databases, including but not limited to: - KNApSAcK database for natural product information - PubChem database for chemical compound data - RCSB Protein Data Bank for protein structure information - ADMETLAB for absorption, distribution, metabolism, excretion, and toxicity predictions - ProTox-III for toxicity prediction - Molsoft for molecular property calculations 4.2 Your use of these third-party integrations is subject to the respective terms of service and usage policies of those providers. Titan Digitalsoft is not responsible for the availability, accuracy, or content of third-party services. 4.3 The Software may download data from these services for computational purposes. You are responsible for ensuring compliance with any applicable usage restrictions or licensing terms of these third-party data sources. 5. ACADEMIC AND RESEARCH USE 5.1 The Software is intended for academic research, educational, and non-commercial purposes. Academic institutions and researchers may use the Software for research purposes without additional licensing fees, provided such use complies with this Agreement. 5.2 Commercial use of the Software requires a separate commercial license agreement with Titan Digitalsoft. Contact support@bioshift.space for commercial licensing information. 6. PRIVACY AND DATA COLLECTION 6.1 The Software does not collect personal information or usage statistics without your explicit consent. 6.2 When you use third-party integrations, data may be transmitted to those services according to their respective privacy policies. Titan Digitalsoft is not responsible for the privacy practices of third-party services. 6.3 Any data you process using the Software remains under your control and responsibility. You are responsible for ensuring compliance with applicable data protection laws and regulations. 7. SUPPORT AND UPDATES 7.1 Titan Digitalsoft may provide technical support and updates for the Software at its discretion. 7.2 Support is provided through the official channels specified in the documentation. 7.3 Titan Digitalsoft is not obligated to provide updates, upgrades, or technical support for the Software. 8. WARRANTY DISCLAIMER 8.1 THE SOFTWARE IS PROVIDED "AS IS" WITHOUT WARRANTY OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, TITLE, AND NON-INFRINGEMENT. 8.2 TITAN DIGITALSOFT DOES NOT WARRANT THAT THE SOFTWARE WILL MEET YOUR REQUIREMENTS, THAT THE OPERATION OF THE SOFTWARE WILL BE UNINTERRUPTED OR ERROR-FREE, OR THAT DEFECTS IN THE SOFTWARE WILL BE CORRECTED. 8.3 THE SOFTWARE INVOLVES COMPLEX COMPUTATIONAL CHEMISTRY AND BIOINFORMATICS OPERATIONS. WHILE EVERY EFFORT HAS BEEN MADE TO ENSURE ACCURACY, THE RESULTS OF COMPUTATIONS SHOULD BE VALIDATED BY QUALIFIED PROFESSIONALS. 8.4 YOU ACKNOWLEDGE THAT COMPUTATIONAL CHEMISTRY AND BIOINFORMATICS ARE HIGHLY SPECIALIZED FIELDS, AND THE SOFTWARE IS PROVIDED AS A RESEARCH TOOL RATHER THAN A CERTIFIED SCIENTIFIC INSTRUMENT. 9. LIMITATION OF LIABILITY 9.1 IN NO EVENT SHALL TITAN DIGITALSOFT OR ITS SUPPLIERS BE LIABLE FOR ANY SPECIAL, INCIDENTAL, INDIRECT, OR CONSEQUENTIAL DAMAGES WHATSOEVER (INCLUDING, WITHOUT LIMITATION, DAMAGES FOR LOSS OF BUSINESS PROFITS, BUSINESS INTERRUPTION, LOSS OF BUSINESS INFORMATION, OR ANY OTHER PECUNIARY LOSS) ARISING OUT OF THE USE OF OR INABILITY TO USE THE SOFTWARE, EVEN IF TITAN DIGITALSOFT HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES. 9.2 IN ANY CASE, TITAN DIGITALSOFT'S ENTIRE LIABILITY UNDER ANY PROVISION OF THIS AGREEMENT SHALL BE LIMITED TO THE AMOUNT ACTUALLY PAID BY YOU FOR THE SOFTWARE. 9.3 SOME JURISDICTIONS DO NOT ALLOW THE LIMITATION OR EXCLUSION OF LIABILITY FOR INCIDENTAL OR CONSEQUENTIAL DAMAGES SO THE ABOVE LIMITATION OR EXCLUSION MAY NOT APPLY TO YOU. 10. TERMINATION 10.1 This Agreement is effective until terminated. You may terminate this Agreement at any time by destroying all copies of the Software and Materials in your possession. 10.2 This Agreement will terminate immediately without notice from Titan Digitalsoft if you fail to comply with any provision of this Agreement. 10.3 Upon termination, you must destroy all copies of the Software and Materials in your possession. 11. GOVERNING LAW AND DISPUTE RESOLUTION 11.1 This Agreement shall be governed by and construed in accordance with the laws of Indonesia, without regard to conflict of law principles. 11.2 Any dispute arising out of or in connection with this Agreement shall be resolved through good faith negotiations between the parties. 11.3 If the dispute cannot be resolved through negotiations, the parties agree to submit to the exclusive jurisdiction of the courts of Indonesia. 12. MISCELLANEOUS 12.1 This Agreement constitutes the entire agreement between you and Titan Digitalsoft with respect to the Software and supersedes all prior or contemporaneous understandings or agreements, written or oral, regarding the subject matter hereof. 12.2 If any provision of this Agreement is held to be unenforceable, such provision shall be reformed only to the extent necessary to make it enforceable. 12.3 This Agreement may not be amended except in writing signed by both parties. 12.4 The failure of either party to enforce any rights granted hereunder or to take action against the other party in the event of any breach hereunder shall not be deemed a waiver by that party as to subsequent enforcement of rights or subsequent actions in the event of future breaches. 13. CONTACT INFORMATION If you have any questions about this Agreement or the Software, please contact: Titan Digitalsoft Email: support@bioshift.space Website: https://bioshift.space Repository: https://github.com/Arifmaulanaazis/Bioshift 14. ACKNOWLEDGMENT BY INSTALLING OR USING THE SOFTWARE, YOU ACKNOWLEDGE THAT YOU HAVE READ THIS AGREEMENT, UNDERSTAND IT, AND AGREE TO BE BOUND BY ITS TERMS AND CONDITIONS. --- Bioshift Version 1.0.0 © 2025 Titan Digitalsoft. All rights reserved. Last updated: August 2025